September 1, 1998Journal of Cardiovascular Pharmacology and Therapeutics
Significance of Supraventricular Tachyarrhythmias After Coronary Artery Bypass Graft Surgery and Their Prevention by Low-Dose Sotalol: A Prospective Double-Blind Randomized Placebo-Controlled Study
Why the study?
Does low-dose sotalol reduce the rate of supraventricular tachyarrhythmias in patients undergoing elective coronary artery bypass graft surgery?
Population
220 consecutive patients referred for elective coronary artery bypass graft surgery
Comparison
Sotalol 80 mg oral twice daily for 3 months… vs Matching placebo
Design
RCT, Randomized to 80 mg sotalol twice daily or matching placebo…
Follow-up
3 months
Authors
Discussion
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Member takes
Implication
May reduce post-CABG hospital stay; confirms low-dose sotalol efficacy for arrhythmia prophylaxis in elective surgery.
Structured PICO
Does low-dose sotalol reduce the rate of supraventricular tachyarrhythmias in patients undergoing elective coronary artery bypass graft surgery?
P
Population
220 consecutive patients referred for elective coronary artery bypass graft surgery
I
Intervention
Sotalol 80 mg oral twice daily for 3 months, with the first dose given 2 hours before surgery
C
Comparator
Matching placebo
O
Outcome
Rate of supraventricular arrhythmiashard clinical
Prophylactic treatment with low-dose sotalol significantly reduces the incidence of supraventricular arrhythmias after CABG surgery, thereby reducing overall hospital stay.
Cite This Study
Weber et al. (1998) studied this question.