Key result
Ribosome-bound EF-Tu separates from the GAC prior to its full separation from aa-tRNA, suggesting EF-Tu·GDP dissociates from the ribosome by two different pathways.
This study elucidates the molecular dynamics of EF-Tu during ribosomal translation, revealing two distinct pathways for EF-Tu·GDP dissociation.
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Advances mechanistic models of translation; leaves open the in vivo relevance and regulatory control of alternative EF-Tu dissociation routes.
Liu et al. (2015) studied this question. Ribosome-bound EF-Tu separates from the GAC prior to its full separation from aa-tRNA, suggesting EF-Tu·GDP dissociates from the ribosome by two different pathways.
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