Key result
Chronic creatine kinase deficiency in mice leads to congestive heart failure by 1 year of age on a mixed genetic background, but only causes mild left ventricular dysfunction without hypertrophy on a pure C57BL/6 background.
Why the study?
Does genetic deletion of creatine kinase lead to congestive heart failure in mice?
Population
Mice deficient in muscle- and mitochondrial-creatine kinase (M/Mt-CK) on a mixed genetic background and…
Comparison
Genetic deletion of muscle- and… vs Wild-type littermate controls or stock C57BL/6…
Design
Preclinical, All data were analysed blind to genotype by a single experienced…
Follow-up
1 year of age
Authors
Loading...
CK deficiency causes strain-dependent HF in mice; leaves open its relevance to human disease and the role of genetic modifiers.
Does genetic deletion of creatine kinase lead to congestive heart failure in mice?
Chronic creatine kinase deficiency can lead to congestive heart failure, but the severity of the phenotype is highly dependent on genetic modifiers, gender, and age.
Lygate et al. (2012) studied Heart failure / Chronic creatine kinase deficiency (n=115). Creatine kinase deficiency (M/Mt-CK-/- knockout) vs. Wild-type mice was evaluated on Left ventricular function and development of congestive heart failure. Chronic creatine kinase deficiency in mice leads to congestive heart failure by 1 year of age on a mixed genetic background, but only causes mild left ventricular dysfunction without hypertrophy on a pure C57BL/6 background.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: