April 1, 1975Diabetes
Hyperinsulinemia and Hypoinsulinemia: Insulin Responses to Oral Carbohydrate Over a Wide Spectrum of Glucose Tolerance
Authors
Discussion
Loading...
Member takes
Implication
Cross-sectional study demonstrates biphasic insulin secretion across varying glucose tolerance in Pima Indians, indicating that early hyperinsulinemia precedes beta-cell secretory exhaustion.
Key Points
- To characterize circulating insulin response patterns to an oral carbohydrate challenge across a continuous spectrum of glucose tolerance.
- Administered a 75 g oral carbohydrate challenge to 396 Pima Indian participants.
- Stratified subjects by 2-hour post-load plasma glucose concentrations to evaluate fasting and post-challenge insulin trajectories.
- Two-hour post-challenge insulin concentrations peaked in individuals with two-hour plasma glucose between 140 and 169 mg/100 ml, after which insulin levels fell progressively as glucose approached 400 mg/100 ml.
- Thirty-minute and one-hour insulin concentrations remained stable up to two-hour glucose levels of 170 mg/100 ml before progressively diminishing at higher glucose concentrations.
- Fasting insulin remained relatively constant across all degrees of glucose intolerance and was predominantly driven by obesity, whereas post-load responses were determined by both glucose level and obesity without influence from age or sex.
Cite This Study
Savage et al. (1975) studied this question.