July 7, 1998Proceedings of the National Academy of SciencesOpen Access

Phospholipase A 2 -mediated activation of mitogen-activated protein kinase by angiotensin II

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Population

Renal proximal tubule epithelial cells

Design

Preclinical

Authors

NDNickolai O. DulinUniversity of Chicago LALarry D. AlexanderMeharry Medical College SHSubash HarwalkarUniversity School

Discussion

Member takes

Implication

Hypothesis-generating for PLA2-CYP mediation of Ang II renal signaling; leaves open human translation and precludes practice change.

Structured PICO

Population

Renal proximal tubule epithelial cells

Intervention

Angiotensin II (Ang II) and arachidonic acid (AA) with or without inhibitors (mepacrine, ketoconazole)

Outcome

Mitogen-activated protein kinase (MAPK) phosphorylation/activationsurrogate

Angiotensin II induces MAPK phosphorylation in renal proximal tubule epithelial cells via a PLA2-dependent release of arachidonic acid and its cytochrome P450-dependent epoxy derivatives.

Cite This Study

Dulin et al. (1998) studied this question.

synapsesocial.com/papers/6a779b00137c7dcc81bdefc5 https://doi.org/10.1073/pnas.95.14.8098

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Phospholipase A 2 -mediated activation of mitogen-activated protein kinase by angiotensin II

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Phospholipase A 2 -mediated activation of mitogen-activated protein kinase by angiotensin II

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider