Why the study?
Does the combination of timolol and hydrochlorothiazide lower blood pressure more effectively than either drug alone in renal hypertensive dogs?
Population
Renal hypertensive dogs
Comparison
Hydrochlorothiazide, timolol, or combinations of… vs Drugs administered alone vs. combination
Design
Preclinical
Follow-up
4 to 7 days
Authors
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May potentiate diuretic BP effects via renin suppression; hypothesis-generating in canine model, human translation unknown.
Does the combination of timolol and hydrochlorothiazide lower blood pressure more effectively than either drug alone in renal hypertensive dogs?
Suppression of diuretic-induced renin release by beta-blockade unmasks the antihypertensive effect of hydrochlorothiazide in a canine model of renal hypertension.
Sweet et al. (1975) studied this question.
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