Why the study?
Does timolol, hydrochlorothiazide-amiloride, or their combination improve blood pressure in patients with primary hypertension?
Population
55 patients with primary hypertension, World Health Organization (WHO) stages I and II
Comparison
Timolol, hydrochlorothiazide combined with… vs Crossover design comparing timolol, AHCT, and…
Design
RCT, Randomly allocated, Double-blind
Follow-up
9 months
Authors
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Combination normalizes BP in most primary hypertension patients; confirms additive efficacy of beta-blocker plus diuretic.
Does timolol, hydrochlorothiazide-amiloride, or their combination improve blood pressure in patients with primary hypertension?
Both timolol and hydrochlorothiazide-amiloride are effective antihypertensives, and their combination normalizes blood pressure in most patients with WHO stage I and II primary hypertension.
Henning et al. (1980) studied this question.
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