Why the study?
Does timolol reduce blood pressure and heart rate in patients with essential hypertension?
Population
20 patients with essential hypertension
Comparison
Timolol in incremental doses during three… vs 4-week placebo run-in period
Design
Cohort
Follow-up
13 weeks (4 weeks placebo + 9 weeks treatment)
Authors
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May support timolol for home BP reduction in essential hypertension; leaves open randomized confirmation of dose-response.
Does timolol reduce blood pressure and heart rate in patients with essential hypertension?
Timolol effectively lowers blood pressure and heart rate in patients with essential hypertension, with the antihypertensive effect not correlating with the fall in plasma renin activity.
Simon et al. (1978) studied this question.
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