Why the study?
Does twice-daily timolol reduce blood pressure and plasma renin activity in patients with mild or moderate hypertension?
Population
8 patients with mild or moderate hypertension
Design
Case_series
Authors
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May support twice-daily timolol in mild hypertension; leaves open confirmation in larger trials.
Does twice-daily timolol reduce blood pressure and plasma renin activity in patients with mild or moderate hypertension?
Twice-daily timolol is effective for mild to moderate hypertension and suppresses plasma renin, with an elimination half-life of 4.7 hours at steady state.
Ishizaki et al. (1978) studied this question.
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