Why the study?
Does the addition of timolol to diuretic therapy improve blood pressure control in hypertensive patients?
Population
65 hypertensive patients, including 35 previously untreated patients with diastolic blood pressure between…
Comparison
Timolol added to diuretic therapy administered… vs Hydrochlorothiazide and a placebo.
Design
Other, Double blind (Study 1) and patient blind (Study 2)
Authors
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Supports timolol addition to hydrochlorothiazide for greater BP reduction; leaves open applicability to modern regimens and long-term outcomes.
Does the addition of timolol to diuretic therapy improve blood pressure control in hypertensive patients?
The addition of timolol to diuretic therapy provides an effective, simplified once-daily regimen for controlling hypertension.
Gillies et al. (1977) studied this question.