Why the study?
Does timolol maleate alone or in combination with hydrochlorothiazide reduce blood pressure in outpatients with mild to moderate uncomplicated essential hypertension compared to hydrochlorothiazide alone?
Population
n=70 outpatients with mild to moderate uncomplicated essential hypertension
Comparison
Timolol maleate alone or in combination with… vs Hydrochlorothiazide alone
Design
RCT, randomized, double-blind
Follow-up
12 weeks
Authors
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Supports combination timolol-hydrochlorothiazide over monotherapy for mild-moderate hypertension; confirms additive BP-lowering benefit in essential HTN.
Does timolol maleate alone or in combination with hydrochlorothiazide reduce blood pressure in outpatients with mild to moderate uncomplicated essential hypertension compared to hydrochlorothiazide alone?
The combination of timolol and hydrochlorothiazide is more effective than either drug alone for reducing blood pressure in mild to moderate essential hypertension.
Leon et al. (1983) studied this question.
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