Why the study?
Does the combination of timolol, hydrochlorothiazide, and amiloride improve blood pressure control compared to timolol alone or hydrochlorothiazide and amiloride in patients with mild to moderate essential hypertension?
Population
54 patients with mild to moderate essential hypertension
Comparison
Timolol, hydrochlorothiazide and amiloride in a… vs Timolol alone or hydrochlorothiazide and…
Design
RCT, randomly assigned, double-blind
Follow-up
6 weeks
Authors
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Supports triple combination over monotherapy or dual therapy for BP control in mild-moderate hypertension; confirms additive benefit in randomized evidence.
Does the combination of timolol, hydrochlorothiazide, and amiloride improve blood pressure control compared to timolol alone or hydrochlorothiazide and amiloride in patients with mild to moderate essential hypertension?
A combination of timolol, hydrochlorothiazide, and amiloride provides superior blood pressure control compared to either component therapy alone in mild to moderate hypertension.
Muiesan et al. (1976) studied this question.
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