Why the study?
Does amiloride-hydrochlorothiazide compared to hydrochlorothiazide alone (with or without timolol) improve metabolic side effects while maintaining antihypertensive efficacy in patients with essential hypertension?
Population
26 patients with mild to moderately severe uncomplicated essential hypertension
Comparison
Amiloride-hydrochlorothiazide 5/50 mg/day vs Hydrochlorothiazide 50 mg/day
Design
RCT, equally randomized, double-blind
Follow-up
12 weeks of active treatment
Authors
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Supports amiloride-hydrochlorothiazide with timolol to avert hypokalemia at equivalent efficacy; extends RCT evidence for potassium-sparing combinations in hypertension.
Does amiloride-hydrochlorothiazide compared to hydrochlorothiazide alone (with or without timolol) improve metabolic side effects while maintaining antihypertensive efficacy in patients with essential hypertension?
Amiloride-hydrochlorothiazide combined with timolol provides equivalent antihypertensive efficacy to hydrochlorothiazide with timolol while preventing hypokalemia.
Chrysant et al. (1983) studied this question.
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