Why the study?
Does concomitant administration of timolol and hydrochlorothiazide/amiloride reduce blood pressure and pulse rate in hypertensive patients?
Population
39 hypertensive patients (28 completed the study)
Comparison
Timolol and hydrochlorothiazide/amiloride… vs Diuretic period (prior/baseline therapy)
Design
Cohort, open
Authors
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May support timolol addition to diuretic in hypertension; hypothesis-generating and should not change practice without RCTs.
Does concomitant administration of timolol and hydrochlorothiazide/amiloride reduce blood pressure and pulse rate in hypertensive patients?
Concomitant administration of timolol and hydrochlorothiazide/amiloride twice daily significantly reduces blood pressure and pulse rate in hypertensive patients compared to diuretic therapy alone.
Hintzen et al. (1978) studied this question.
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