Effect of timolol versus propranolol on hypertension and hemodynamics.
Why the study?
Does timolol compared to propranolol improve hypertension and hemodynamics in men?
Population
20 men with hypertension
Comparison
Timolol 30 to 60 mg daily for five weeks vs Propranolol 240 to 480 mg daily for five weeks
Design
RCT, randomized, double-blind
Follow-up
5 weeks
Authors
Discussion
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Member takes
Implication
Timolol offers a comparable alternative to propranolol; confirms equivalent beta-blocker effects on BP, HR, and hemodynamics in hypertension.
Structured PICO
Does timolol compared to propranolol improve hypertension and hemodynamics in men?
P
Population
20 men with hypertension
I
Intervention
Timolol 30 to 60 mg daily for five weeks
C
Comparator
Propranolol 240 to 480 mg daily for five weeks
O
Outcome
Supine and upright systolic and diastolic blood pressure, heart rate, hemodynamics (cardiac index), and plasma renin activitysurrogate
Timolol and propranolol demonstrate equivalent efficacy in lowering blood pressure and heart rate, with comparable hemodynamic effects.
Cite This Study
Aronow et al. (1976) studied this question.