Why the study?
Exercise-induced arrhythmogenic right ventricular cardiomyopathy is an under-recognized clinical entity without genetic abnormalities that shares overlapping features with athlete's heart.
Does exercise detraining reverse cardiac remodeling in exercise-induced arrhythmogenic right ventricular cardiomyopathy?
Does exercise detraining reverse cardiac remodeling in exercise-induced arrhythmogenic right ventricular cardiomyopathy?
Exercise detraining in a patient with exercise-induced ARVC led to complete normalization of right ventricular size and function, suggesting the condition may be acquired and reversible.
Exercise-induced ARVC without genetic variants merits recognition in athletes; leaves open the role of detraining and selective EP mapping.
Key Teaching Points•Exercise-induced arrhythmogenic right ventricular cardiomyopathy (ARVC) is an under-recognized clinical entity without genetic abnormalities that has overlapping features of ARVC and athlete’s heart.•An invasive electrophysiology study with programmed ventricular stimulation and high-definition endocardial voltage mapping may aid in the risk stratification process in select patients, although routine use is cautioned.•In this case, exercise detraining may have a role in reversing the exercise-induced ARVC phenotype. •Exercise-induced arrhythmogenic right ventricular cardiomyopathy (ARVC) is an under-recognized clinical entity without genetic abnormalities that has overlapping features of ARVC and athlete’s heart.•An invasive electrophysiology study with programmed ventricular stimulation and high-definition endocardial voltage mapping may aid in the risk stratification process in select patients, although routine use is cautioned.•In this case, exercise detraining may have a role in reversing the exercise-induced ARVC phenotype.
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Darden et al. (2022) studied this question.
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