December 5, 2012PLoS ONEOpen Access

Cardiac Ankyrin Repeat Protein Attenuates Cardiac Hypertrophy by Inhibition of ERK1/2 and TGF-β Signaling Pathways

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Why the study?

Does CARP overexpression prevent cardiac hypertrophy in response to pressure overload and neurohumoral stimulation in preclinical models?

Population

Cardiac-specific CARP-overexpressing transgenic mice and isolated neonatal Sprague-Dawley rat cardiomyocytes.

Comparison

Overexpression of CARP. vs Wild-type littermates and Ad-GFP infected or…

Design

Preclinical

Follow-up

4 weeks (TAC model) and 14 days (isoproterenol model)

Authors

YSYao SongJiangnan University JXJialin XuXiamen University YLYanfeng LiPeking University

Discussion

Member takes

Implication

CARP may protect against pressure-overload hypertrophy; hypothesis-generating and leaves open clinical translation.

Structured PICO

Does CARP overexpression prevent cardiac hypertrophy in response to pressure overload and neurohumoral stimulation in preclinical models?

Population

Cardiac-specific CARP-overexpressing transgenic mice (a-MHC-CARP, 129 strain backcrossed to C57/BL6J) and isolated neonatal Sprague-Dawley rat cardiomyocytes.

Intervention

Overexpression of CARP (in vivo via a-MHC promoter transgenesis, in vitro via Ad-CARP-GFP adenovirus).

Comparator

Wild-type littermates (in vivo) and Ad-GFP infected or non-infected cells (in vitro).

Outcome

Cardiac hypertrophy assessed by heart weight/body weight ratio, echocardiography (LVPW;d, LV mass), histological myocyte area, and hypertrophic marker expression.surrogate

CARP functions as an anti-hypertrophic factor in the heart by attenuating pressure overload- and agonist-induced hypertrophy through inhibition of the ERK1/2 and TGF-β signaling pathways.

Cite This Study

Song et al. (2012) studied this question.

synapsesocial.com/papers/6a77bee4f6b553d308aeb6df https://doi.org/10.1371/journal.pone.0050436

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Cardiac Ankyrin Repeat Protein Attenuates Cardiac Hypertrophy by Inhibition of ERK1/2 and TGF-β Signaling Pathways

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cardiac Ankyrin Repeat Protein Attenuates Cardiac Hypertrophy by Inhibition of ERK1/2 and TGF-β Signaling Pathways

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider