Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 1, 1997Journal of Biological ChemistryOpen Access

The Kidney Androgen-regulated Protein Promoter Confers Renal Proximal Tubule Cell-specific and Highly Androgen-responsive Expression on the Human Angiotensinogen Gene in Transgenic Mice

View Full Paper
Ask AI
Bookmark
Share

Population

Transgenic mice containing a 1542-base pair fragment of the kidney androgen-regulated protein promoter fused…

Comparison

Administration of testosterone (in female mice) vs Basal conditions (no testosterone)

Design

Preclinical

Authors

YDYueming DingNanjing Medical UniversityRDRobin L. DavissonGeneral CardiologyDHDianne O. HardyMind Australia

Discussion

Loading...

Member takes

Implication

Enables targeted inducible RAS expression in mouse proximal tubules; leaves open translation to human renal disease models.

Structured PICO

P
Population
Transgenic mice containing a 1542-base pair fragment of the kidney androgen-regulated protein (KAP) promoter fused to the human angiotensinogen (HAGT) gene
I
Intervention
Administration of testosterone (in female mice)
C
Comparator
Basal conditions (no testosterone)
O
Outcome
Expression of human angiotensinogen (HAGT) gene in the kidneysurrogate

The KAP promoter can specifically target inducible expression of renin-angiotensin system components to the kidney proximal tubule cells in transgenic mice.

Cite This Study

Ding et al. (1997) studied this question.

synapsesocial.com/papers/6a77c08aa7498e5110aed2eehttps://doi.org/10.1074/jbc.272.44.28142
View Full Paper
Ask AI
Bookmark
Share