What question did this study set out to answer?

November 1, 1992Pacing and Clinical Electrophysiology

Diastolic Mitral Regurgitation in Patients with First‐Degree Atrioventricular Block

View Full Paper

Ask AI

Bookmark

Why the study?

Does atropine sulfate IV reduce diastolic mitral regurgitation in patients with first-degree AV block?

Population

33 patients with normal cardiac function, comprising 24 patients with first-degree AV block and 9 patients…

Comparison

1 mg atropine sulfate IV and prolongation of AV… vs Baseline state.

Design

Cross-sectional

Authors

TIToshiyuki IshikawaTokyo Metropolitan Matsuzawa Hospital KKKazuo KimuraInterventional Cardiology NMNaomichi MiyazakiYokohama City University

Discussion

Member takes

Implication

Diastolic MR may respond to PQ shortening in first-degree AV block; hypothesis-generating and requires prospective confirmation before practice change.

Key Points

To investigate the occurrence and mechanisms of diastolic mitral regurgitation in patients with first-degree atrioventricular block and DDD pacemakers.
Evaluated transmitral blood flow using pulsed Doppler echocardiography in 24 patients with first-degree AV block (mean age 35.3 ± 17.4 years) and 9 patients with DDD pacemakers (mean age 73.1 ± 8.1 years).
Administered 1 mg of intravenous atropine sulfate to assess the hemodynamic effects of pharmacologically shortening the PQ interval.
Diastolic mitral regurgitation was present in 19 of 24 (79.2%) patients with first-degree AV block, with a critical PQ interval threshold of 0.23 ± 0.01 seconds.
Atropine sulfate significantly reduced the PQ interval from 0.32 ± 0.06 to 0.20 ± 0.05 seconds (P < 0.01) and shortened regurgitation duration from 0.15 ± 0.03 to 0.05 ± 0.03 seconds (P < 0.01), with a significant correlation between both changes (r = 0.92, P < 0.001).

Structured PICO

Does atropine sulfate IV reduce diastolic mitral regurgitation in patients with first-degree AV block?

Population

33 patients with normal cardiac function, comprising 24 patients with first-degree AV block (mean age 35.3 +/- 17.4 years) and 9 patients with DDD pacemakers (mean age 73.1 +/- 8.1 years).

Intervention

1 mg atropine sulfate IV (in the first-degree AV block group) and prolongation of AV delay (in the DDD pacemaker group).

Comparator

Baseline state (prior to atropine administration or AV delay prolongation).

Outcome

Presence and duration of diastolic mitral regurgitation and changes in PQ interval, measured by pulsed Doppler echocardiography.surrogate

Prolonged PQ intervals in first-degree AV block or DDD pacing can lead to diastolic mitral regurgitation due to delayed ventricular contraction following atrial contraction.

Cite This Study

Ishikawa et al. (1992) studied this question.

synapsesocial.com/papers/6a77c243d8eb58afc2be1b4c https://doi.org/10.1111/j.1540-8159.1992.tb02996.x

Topics

Mitral valve intervention

View Full Paper

Ask AI

Bookmark

Implication

Diastolic MR may respond to PQ shortening in first-degree AV block; hypothesis-generating and requires prospective confirmation before practice change.

Diastolic Mitral Regurgitation in Patients with First‐Degree Atrioventricular Block

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Diastolic Mitral Regurgitation in Patients with First‐Degree Atrioventricular Block

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider