Why the study?
Does transient pulmonary artery constriction induce persistent right ventricular failure through activation of apoptotic pathways in mongrel dogs?
Population
14 anesthetized mongrel dogs
Comparison
Transient 90-min pulmonary artery constriction… vs Sham operation
Design
Preclinical, randomized
Follow-up
30 mins post-operation
Authors
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Transient PA constriction activates RV apoptosis in dogs; hypothesis-generating, requires human validation before clinical consideration.
Does transient pulmonary artery constriction induce persistent right ventricular failure through activation of apoptotic pathways in mongrel dogs?
Acute afterload-induced persistent right ventricular failure is associated with early activation of apoptotic pathways and local overexpression of TNF-alpha.
Dewachter et al. (2010) studied this question.
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