Familial Resemblance of Plasma Lipids, Lipoproteins and Postheparin Lipoprotein and Hepatic Lipases in the HERITAGE Family Study
Population
437 sedentary Caucasian individuals from 86 families participating in the HERITAGE Family study
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
High heritability of lipid traits supports family screening; leaves open whether genetic testing refines risk prediction in prospective studies.
Structured PICO
P
Population
437 sedentary Caucasian individuals (171 parents and 266 adult offspring) from 86 families participating in the HERITAGE Family study
O
Outcome
Familial resemblance (heritability) of plasma levels of total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, and postheparin plasma lipoprotein lipase (LPL) and hepatic lipase (HL) activitiessurrogate
Genetic factors are major determinants of familial resemblance in plasma lipids and lipoproteins, with heritability estimates ranging from 50% to 83% for cholesterol fractions.
Cite This Study
Përusse et al. (1997) studied this question.