July 1, 1987Arteriosclerosis An Official Journal of the American Heart Association Inc

Inheritance of high density lipoprotein and lipoprotein lipase and hepatic lipase activity.

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Population

17 monozygotic and 18 dizygotic male twin pairs randomly selected from the Finnish Twin Cohort Study.

Design

Cross-sectional

Authors

TKT KuusiUniversity of Helsinki YKY. Antero KesäniemiBroad Institute MVMatti VuoristoUniversity of Helsinki

Discussion

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Implication

Supports genetic regulation of HDL traits via hepatic lipase; hypothesis-generating and should not yet change practice.

Structured PICO

Population

17 monozygotic (MZ) and 18 dizygotic (DZ) male twin pairs (n=70 individuals) randomly selected from the Finnish Twin Cohort Study.

Outcome

Heritability estimates of plasma HDL, HDL subfractions (HDL2, HDL3), major HDL apoproteins (apo A-I and A-II), and activities of lipoprotein lipase (LPL) and hepatic lipase (HL)surrogate

The study suggests that genetic regulation of HDL and its subfractions is significant and may be partially mediated through hepatic lipase activity.

Cite This Study

Kuusi et al. (1987) studied this question.

synapsesocial.com/papers/6a79ccb977336a1bae027eaa https://doi.org/10.1161/01.atv.7.4.421

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Inheritance of high density lipoprotein and lipoprotein lipase and hepatic lipase activity.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inheritance of high density lipoprotein and lipoprotein lipase and hepatic lipase activity.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider