Why the study?
Does α(1)-blockade with prazosin reduce orthostatic tolerance time during head-upward tilt in normotensive volunteers?
Population
12 normotensive volunteers, mean age 25 ± 1 years
Comparison
Prazosin administered 90 min prior to 60°… vs Placebo administered 90 min prior to 60°…
Design
RCT, randomized, placebo-controlled
Follow-up
15 minutes
Authors
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α(1)-blockade may heighten syncope risk via impaired orthostatic tolerance; confirms α(1)-sympathetic vasoconstriction as critical, especially mornings.
Does α(1)-blockade with prazosin reduce orthostatic tolerance time during head-upward tilt in normotensive volunteers?
α(1)-sympathetic vasoconstrictor activity plays a critical role in maintaining orthostatic tolerance and preventing syncope, particularly in the early morning.
Lewis et al. (2012) studied this question.
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