Why the study?
Does the time of day (morning vs afternoon) affect the time to presyncope during a controlled orthostatic challenge in normotensive volunteers?
Population
17 normotensive volunteers, aged 26 +/- 4 yr (mean +/- SD)
Comparison
Orthostatic challenge conducted in the morning vs Same orthostatic challenge conducted in the…
Design
Other
Authors
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Morning orthostatic intolerance may raise syncope risk; leaves open whether testing protocols should account for diurnal variation.
Does the time of day (morning vs afternoon) affect the time to presyncope during a controlled orthostatic challenge in normotensive volunteers?
Orthostatic tolerance is significantly reduced in the morning, driven by diurnal variations in baseline cerebral blood flow velocity and time-based blood pressure decline, which may explain the higher morning risk of neurally mediated syncope.
Lewis et al. (2010) studied this question.
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