Key result
Older age is associated with lower cerebral tissue oxygenation prior to syncope in patients with vasovagal syncope (p=0.009) and orthostatic hypotension (p<0.001) compared to younger individuals.
Why the study?
Age-related physiological impairment increases syncope susceptibility, but whether cerebral oxygenation during orthostatic provocation and syncope differs according to age was unclear.
Does age influence cerebral tissue oxygenation during orthostatic provocation in patients with vasovagal syncope and orthostatic hypotension?
Population
139 vasovagal syncope, 121 orthostatic hypotension, and 82 negative head-up tilt test patients
Comparison
Age groups of <30 vs 30-60 vs >60 years
Design
Observational cross-sectional study
Authors
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Lower presyncopal cerebral oxygenation in older syncope patients may support age-adjusted thresholds; leaves open whether oximetry refines management.
Observational (n=342)
Does age influence cerebral tissue oxygenation during orthostatic provocation in patients with vasovagal syncope and orthostatic hypotension?
p-value: p=<0.001
Older individuals with vasovagal syncope and orthostatic hypotension have lower cerebral oxygenation prior to syncope compared to younger individuals, suggesting the threshold for syncope is lower in older age.
Kharraziha et al. (2022) conducted an observational in Vasovagal syncope and orthostatic hypotension (n=342). Older age vs. Younger age was evaluated on Cerebral tissue oxygenation at the presyncopal phase (p=<0.001). Older age is associated with lower cerebral tissue oxygenation prior to syncope in patients with vasovagal syncope (p=0.009) and orthostatic hypotension (p<0.001) compared to younger individuals.
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