Population
Intact human umbilical vein endothelial cells (HUVECs)
Design
Preclinical
Authors
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Does not alter clinical vascular management; leaves open translation of thrombin-cAMP signaling to human endothelial barrier therapies.
Thrombin transiently decreases cAMP levels in endothelial cells via Ca(2+)-dependent inhibition of adenylyl cyclase 6, providing mechanistic insight into endothelial barrier regulation.
Werthmann et al. (2009) studied this question.
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