Why the study?
Complete surgical excision of massive retroperitoneal liposarcomas is technically challenging, and compartmental resection has been advocated to improve oncological outcomes and local recurrence.
This case demonstrates the safety and feasibility of compartmental resection in achieving R0 resection in massive retroperitoneal liposarcoma.
Case report supports compartmental resection feasibility in massive retroperitoneal liposarcoma; leaves open its oncologic benefit versus standard excision.
Retroperitoneal liposarcomas are uncommon malignancies that often remain clinically silent and may attain massive size at diagnosis. Complete surgical excision with negative margins is the cornerstone of treatment; however, this is technically challenging due to indistinct anatomical planes and proximity to major vascular and visceral structures. Compartmental resection has been advocated to improve oncological outcomes, particularly with regard to local recurrence. We report a 43-year-old hypertensive male who presented with progressive abdominal distension and left-sided abdominal pain. Imaging demonstrated a large fat-containing retroperitoneal mass extending across the midline with multivisceral involvement. The patient underwent left-sided compartmental resection, including left nephrectomy, distal pancreaticosplenectomy, and left hemicolectomy. The resected specimen weighed 18 kg. Histopathology reported a dedifferentiated liposarcoma with negative margins. This case demonstrates the safety and feasibility of compartmental resection in achieving R0 resection in massive retroperitoneal liposarcoma.
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Ghei et al. (2026) studied this question.
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