KCNQ1 Channels Sense Small Changes in Cell Volume
Population
Xenopus oocytes co-expressing KCNQ1 or KCNQ4 channels with aquaporin 1 water-channels (AQP1)
Comparison
Small cell volume changes, incubation in… vs KCNQ2 and KCNQ3 channels
Design
Preclinical
Authors
Discussion
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Member takes
Implication
KCNQ1/4 may act as volume sensors in native cells; leaves open relevance to mammalian physiology or disease.
Structured PICO
P
Population
Xenopus oocytes co-expressing KCNQ1 or KCNQ4 channels with aquaporin 1 water-channels (AQP1)
I
Intervention
Small cell volume changes, incubation in cytochalasin D, and use of truncated KCNQ1 channels
C
Comparator
KCNQ2 and KCNQ3 channels
O
Outcome
KCNQ1 and KCNQ4 current amplitudessurrogate
KCNQ1 and KCNQ4 channels act as sensors for small cell volume changes, likely mediated through interactions between the cytoskeleton and the N-terminus of the channel protein.
Cite This Study
Grunnet et al. (2003) studied this question.