January 1, 2002The Japanese Journal of PhysiologyOpen Access

Role of KCNQ1 in the Cell Swelling-Induced Enhancement of the Slowly Activating Delayed Rectifier K+ Current.

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Population

Heterologous mammalian cell line transiently expressing KCNQ1 alone or together with KCNE1

Comparison

Exposure to hyposmotic solutions with or without… vs Control osmolarity and cells without exogenous…

Design

Preclinical

Authors

TKTomoyuki KubotaKamiichi General Hospital MHMinoru HorieElectrophysiology MTMakoto TakanoChiba Hokusou Hospital

Discussion

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Implication

KCNQ1 mediates osmotic I(Ks) enhancement independently of PTK; leaves open relevance to human volume-related arrhythmias.

Structured PICO

Population

Heterologous mammalian cell line transiently expressing KCNQ1 alone or together with KCNE1

Intervention

Exposure to hyposmotic solutions (0.7 times control osmolarity) with or without protein tyrosine kinase (PTK) or phosphotyrosine phosphatase (PTP) inhibitors (genistein, orthovanadate, AMP-PNP)

Comparator

Control osmolarity and cells without exogenous channels

Outcome

Whole-cell membrane currents (I(Ks) enhancement)surrogate

KCNQ1 primarily participates in the I(Ks) enhancement by osmotic cell swelling, independent of protein tyrosine kinase activity in a mammalian expression system.

Cite This Study

Kubota et al. (2002) studied this question.

synapsesocial.com/papers/6a77dd34576efb0ddaf7b14c https://doi.org/10.2170/jjphysiol.52.31

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Role of KCNQ1 in the Cell Swelling-Induced Enhancement of the Slowly Activating Delayed Rectifier K+ Current.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role of KCNQ1 in the Cell Swelling-Induced Enhancement of the Slowly Activating Delayed Rectifier K+ Current.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider