Population
Necturus proximal tubule cells (n=7 tubules)
Comparison
Pipette suction and 50% reduction in bath… vs Baseline state
Design
Preclinical
Authors
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Supports stretch-activated K+ channels mediating osmoregulation in amphibian tubules; leaves open relevance to mammalian or clinical volume control.
Stretch-activated K+ channels mediate the increase in macroscopic K+ conductance during osmoregulation in amphibian proximal tubules.
Henry Sackin (1989) studied this question.
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