Antithrombotic Therapy After Transcatheter Aortic Valve Replacement: A Meta-analysis and Trial Sequential Analysis of Randomized Trials

Figures

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  Figure 1. Forest plot of hazard ratios (HR) for mortality comparing novel oral anticoagulants (NOAC) versus comparator: (A) patients without an indication for anticoagulation,2,5,7 and (B) patients with an indication for anticoagulation.5,6 Trial sequential analysis (TSA) for mortality in (C) patients without an indication for anticoagulation, and (D) patients with an indication for anticoagulation. AIS, achieved information size; esOF, Lan & DeMets version of O'Brien-Fleming; HARIS, heterogeniety adjusted required information size; MH, Mantel-Haenszel; SW, stage-wise.

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  Supplemental Figure 1.