Why the study?
Does a telmisartan and nifedipine combination reduce 24-hour ambulatory blood pressure in untreated hypertensive patients during acute high-altitude exposure compared to placebo?
Population
100 untreated subjects with mild hypertension. 89 completed the study.
Comparison
Telmisartan 80 mg + modified release nifedipine… vs Double-blind placebo
Design
RCT, randomized, double-blind
Follow-up
6 weeks at sea level plus acute high altitude exposure
Authors
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Supports telmisartan-nifedipine for BP control in hypertensives at high altitude; extends evidence to acute altitude exposure.
Does a telmisartan and nifedipine combination reduce 24-hour ambulatory blood pressure in untreated hypertensive patients during acute high-altitude exposure compared to placebo?
In patients with mild hypertension, acute high-altitude exposure significantly increases 24-hour blood pressure, which can be effectively and safely reduced by a telmisartan-nifedipine combination.
Bilo et al. (2015) studied this question.
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