Why the study?
Does propranolol prevent the increase in systemic arterial blood pressure associated with high altitude residence in healthy men?
Population
11 healthy men
Comparison
Propranolol during 3 weeks of residence at 4,300 m vs Placebo during 3 weeks of residence at 4,300 m
Design
Other
Follow-up
3 weeks
Authors
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Propranolol only partially attenuates altitude-induced BP rise in healthy men; hypothesis-generating for beta-blockade effects on altitude-related cardiovascular risk.
Does propranolol prevent the increase in systemic arterial blood pressure associated with high altitude residence in healthy men?
High altitude induces a progressive increase in systemic blood pressure associated with increased sympathoadrenal activity, which is only partially attenuated by beta-blockade with propranolol.
Wolfel et al. (1994) studied this question.
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