December 1, 2001Journal of Biological ChemistryOpen Access

Differences in Three Kinetic Parameters Underpin the Unique Catalytic Profiles of Nitric-oxide Synthases I, II, and III

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Population

Kinetic simulation model of neuronal, inducible, and endothelial nitric-oxide synthases (nNOS, iNOS, and eNOS)

Design

Preclinical

Authors

JSJérôme SantoliniUniversité Paris-Sud AMAbigail L. Meade DSDennis J. StuehrVascular Medicine

Discussion

Member takes

Implication

Clarifies NOS isoform kinetics in vitro; leaves open translation to cardiovascular NO-targeted therapies.

Structured PICO

Population

Kinetic simulation model of neuronal, inducible, and endothelial nitric-oxide synthases (nNOS, iNOS, and eNOS)

Intervention

Kinetic simulation modeling of catalytic behaviors and NOS.NO interactions

Outcome

Catalytic behaviors of NOS isoforms (speed and extent of heme.NO complex accumulation, K(m) for O(2), and propensity to transform NO into a higher oxide)

A unified kinetic model explains the distinct catalytic behaviors and regulation of different nitric-oxide synthase isoforms based on three basic kinetic parameters.

Cite This Study

Santolini et al. (2001) studied this question.

synapsesocial.com/papers/6a77edddd2fa2470761f3272 https://doi.org/10.1074/jbc.m108666200

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Differences in Three Kinetic Parameters Underpin the Unique Catalytic Profiles of Nitric-oxide Synthases I, II, and III

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Differences in Three Kinetic Parameters Underpin the Unique Catalytic Profiles of Nitric-oxide Synthases I, II, and III

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider