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October 1, 1991AJP Heart and Circulatory Physiology

Adriamycin-induced myocardial dysfunction in vitro is mediated by free radicals

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Why the study?

Do antioxidants reduce adriamycin-induced myocardial dysfunction in vitro?

Population

Papillary muscles (in vitro model)

Comparison

Antioxidants (catalase 4 x 10 U/l, mannitol 20… vs Adriamycin alone

Design

Preclinical

Follow-up

60 min

Authors

VLVivian K LeeKing's College LondonARA. K. RandhawaSt. Boniface HospitalPSPawan K. SingalHeart Failure / Cardiomyopathy

Discussion

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Implication

Antioxidants may attenuate adriamycin cardiotoxicity in vitro; hypothesis-generating for radical-mediated mechanisms, with no clinical implications yet.

Structured PICO

Do antioxidants reduce adriamycin-induced myocardial dysfunction in vitro?

P
Population
Papillary muscles (in vitro model)
I
Intervention
Antioxidants (catalase 4 x 10(4) U/l, mannitol 20 mM, or superoxide dismutase 1.2 x 10(5) U/l) added to adriamycin (100 microM)
C
Comparator
Adriamycin alone
O
Outcome
Developed force, lipid peroxidation, and ultrastructural changessurrogate

This in vitro study suggests that hydrogen peroxide and hydroxyl radicals mediate the acute myocardial dysfunction induced by adriamycin.

Cite This Study

Lee et al. (1991) studied this question.

synapsesocial.com/papers/6a780412f6b553d308aeecafhttps://doi.org/10.1152/ajpheart.1991.261.4.h989

Topics

Cardiomyopathy
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relation between cardiotoxic effect of adriamycin and superoxide anion radical.1983 · 27 citations
  2. 2Adriamycin-induced oxidative stress, activation of MAP kinases and apoptosis in isolated cardiomyocytes2006 · 44 citations
  3. 3Free Radicals Mediate Cardiac Toxicity Induced by Adriamycin2003 · 12 citations
  4. 4Effects of Pyrrolidine Dithiocarbamate on Antioxidant Enzymes in Cardiomyopathy Induced by Adriamycin in Rats2008 · 13 citations
  5. 5Adriamycin stimulates low-affinity Ca2+ binding and lipid peroxidation but depresses myocardial function1986 · 105 citations