Why the study?
Does olmesartan/hydrochlorothiazide combination therapy improve blood pressure control compared to monotherapy in patients with essential hypertension?
Population
Patients with essential hypertension, including moderate to severe hypertension
Comparison
Olmesartan and hydrochlorothiazide combination… vs Olmesartan monotherapy or HCTZ monotherapy
Design
Review
Authors
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May support use after monotherapy failure; leaves open randomized head-to-head trials versus other combinations.
Does olmesartan/hydrochlorothiazide combination therapy improve blood pressure control compared to monotherapy in patients with essential hypertension?
Olmesartan/HCTZ combination therapy is an effective and well-tolerated option for managing essential hypertension, particularly in patients requiring significant blood pressure reductions.
Luís M. Ruilope (2008) studied this question.
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