Population
Dog heart model of early myocardial infarction
Comparison
Coronary ligation (ischemia) vs Normal myocardial cells
Design
Preclinical
Follow-up
up to 12 hours
Authors
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Early ATPase decline may mark ischemic irreversibility; leaves open its value as a reversible-injury biomarker pending human validation.
A decrease in ATPase activity occurs early in myocardial ischemia alongside structural changes, indicating ischemic irreversibility.
Ozawa et al. (1982) studied this question.
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