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August 9, 2026Journal of Leukocyte BiologyOpen Access

Obesity hampers bacteria killing by human neutrophils

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Authors

NNNathalia Naranjo-PintoCBCarlos Blanco-CamarilloNMNancy Mora

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Overview

Randomized trial evaluates neutrophil function in obesity, revealing impaired pathogen-specific killing mechanisms.

Key Points

  • This research aims to determine how obesity affects the antimicrobial functions of neutrophils.
  • Neutrophils were isolated from individuals with normal weight and obesity.
  • The phenotype and microbicidal functions of neutrophils were assessed, including respiratory burst and NET formation.
  • Pathogen-specific killing was evaluated against Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella quasipneumoniae.
  • Neutrophils from individuals with obesity showed higher expression of activation markers (CD66b, CD11b).
  • Killing efficacy of Pseudomonas aeruginosa and Klebsiella quasipneumoniae was impaired in neutrophils from individuals with obesity.
  • Phagocytosis and NET formation were comparable, but NET formation against Staphylococcus aureus was selectively reduced.

Cite This Study

Naranjo-Pinto et al. (2026) studied this question.

synapsesocial.com/papers/6a782d4e2e1896536c8403a4https://doi.org/10.1093/jleuko/qiag111
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