Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 1, 1977Scandinavian Journal of Haematology

Obese subjects had significantly decreased PMN bactericidal capacity and increased PMN adherence, as well as higher plasma triglycerides and free fatty acids, though granulocyte changes did not correlate with lipid levels or body weight.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does obesity alter polymorphonuclear granulocyte functions and plasma lipids compared to normal weight?

Population

40 subjects (20 obese subjects and 20 normal weight controls)

Comparison

Obesity (observational) vs Normal weight controls

Design

Case-control

Authors

JPJan PalmbladDHD HallbergSRStephan Rössner

Discussion

Loading...

Member takes

Overview

Obesity-linked PMN impairment may raise infection risk independent of lipids; hypothesis-generating, should not yet change practice.

Structured PICO

Does obesity alter polymorphonuclear granulocyte functions and plasma lipids compared to normal weight?

P
Population
40 subjects (20 obese subjects and 20 normal weight controls)
I
Intervention
Obesity (observational)
C
Comparator
Normal weight controls
O
Outcome
Polymorphonuclear (PMN) granulocyte functions (bactericidal capacity, adherence, chemotaxis, opsonic capacity) and plasma lipidssurrogate

Obesity is associated with altered PMN granulocyte function, including decreased bactericidal capacity and increased adherence, independent of plasma lipid levels.

Cite This Study

Palmblad et al. (1977) studied this question.

synapsesocial.com/papers/6a71420cfebe604dd709f487https://doi.org/10.1111/j.1600-0609.1977.tb02109.x
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Obesity hampers bacteria killing by human neutrophils2026
  2. 2Dysregulated Myelopoiesis and Altered Neutrophil Metabolism in Obese Adults: A Role for Glutaminase in Hypoxia-Induced Cell Survival 22601302026
  3. 3Diminished FcγRIIa expression reduces antibody-mediated phagocytosis by low-density neutrophils in obesity2026
  4. 4Leukocyte Activation in Obese Patients2015 · 13 citations
  5. 5Peripheral Blood Mononuclear Cells Oxidative Stress and Plasma Inflammatory Biomarkers in Adults with Normal Weight, Overweight and Obesity2021 · 27 citations