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August 9, 2026Clinical Physiology and Functional Imaging

Diagnostic and prognostic value of left atrioventricular coupling index post revascularization in acute coronary syndrome: A two‐dimensional echocardiographic study

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Key result

PCI normalizes LACI in ~48% of ACS patients with baseline impairment.

  • n=193

Why the study?

The study aimed to evaluate the left atrioventricular coupling index (LACI) by echocardiography before and after PCI compared with LV ejection fraction in patients with acute coronary syndrome.

Does percutaneous coronary intervention improve left atrioventricular coupling index (LACI) and LV ejection fraction in patients with acute coronary syndrome?

Population

193 ACS patients who underwent PCI

Comparison

LACI vs LV-EF before and after PCI

Design

Retrospective cohort analysis

Follow-up

12.8 ± 8.2 months

Authors

AAAshraf M. AnwarCardiac ImagingAAAbdelrahman AlmalkiKing Fahd Armed Forces HospitalWDWesam DausCardiac Imaging

Discussion

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Implication

LACI may improve post-PCI in select ACS patients; leaves open its incremental prognostic value over LVEF.

Key Points

  • To evaluate the left atrioventricular coupling index (LACI) via echocardiography in patients with acute coronary syndrome before and after PCI.
  • Retrospective cohort analysis of 193 ACS patients who underwent PCI.
  • Calculated LACI and LV ejection fraction (LV-EF) before and after PCI.
  • Follow-up duration averaged 12.8 months post PCI.
  • At presentation, 80.8% (156 patients) had reduced LV-EF, with varied severity levels.
  • Post PCI, LV-EF normalized in 17.9% (28 patients) of those with initial reductions.
  • LACI normalized in 47.5% (19 patients) of 40 with impaired baseline LACI.

Study Design

Type

Cohort (n=193)

Structured PICO

Does percutaneous coronary intervention improve left atrioventricular coupling index (LACI) and LV ejection fraction in patients with acute coronary syndrome?

P
Population
193 patients with acute coronary syndrome (mean age 65.1 years, 28.4% female) who underwent percutaneous coronary intervention, followed for a mean of 12.8 months.
E
Exposure
Percutaneous coronary intervention (PCI) with echocardiographic assessment of left atrioventricular coupling index (LACI) and LV ejection fraction (LV-EF) before and after.
O
Outcome
Changes in left atrioventricular coupling index (LACI) and LV ejection fraction (LV-EF) post-PCIsurrogate

Assessment of left atrioventricular coupling index (LACI) provides insight into LA and LV dynamics in ACS, and its normalization post-PCI may indicate better prognosis.

Cite This Study

Anwar et al. (2026) conducted a cohort in Acute coronary syndrome (n=193). Percutaneous coronary intervention (PCI) vs. Baseline (pre-PCI) was evaluated on Normalization of left atrioventricular coupling index (LACI) and improvement in LV-EF. Following percutaneous coronary intervention in acute coronary syndrome patients, the left atrioventricular coupling index normalized in 47.5% of those with baseline impairment.

synapsesocial.com/papers/6a782d7b2e1896536c840a53https://doi.org/10.1111/cpf.70086

Topics

Percutaneous coronary intervention
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Patterns of Left-Ventricular Function Assessment in Patients With Acute Coronary Syndromes2021 · 11 citations
  2. 2Change in Left Ventricular Ejection Fraction With Coronary Artery Revascularization and Subsequent Risk for Adverse Cardiovascular Outcomes2022 · 28 citations
  3. 3Left Atrial Remodeling Following ST‐Segment–Elevation Myocardial Infarction Correlates With Infarct Size and Age Older Than 70 Years2023 · 8 citations
  4. 4Extent of Ejection Fraction Improvement After Revascularization Associated with Outcomes Among Patients with Ischemic Left Ventricular Dysfunction2022 · 8 citations
  5. 5Percutaneous Revascularization for Ischemic Left Ventricular Dysfunction2022 · 577 citations