Renin in thymus, gut, hindlimb, and adrenal of (mRen-2)27 and normal rats: secretion and content studies

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Population

(mRen-2)27 rats and normal Sprague-Dawley rats

Design

Preclinical

Follow-up

12 hours

Authors

Discussion

Hypothesis-generating for extrarenal renin sources in rats; leaves open relevance to human cardiovascular disease.

Population

(mRen-2)27 rats and normal Sprague-Dawley rats

Intervention

Removal of kidneys and adrenals (nephrectomy and adrenalectomy), and thymic ablation

Outcome

Plasma levels and organ content of active renin and proreninsurrogate

The thymus and gut are significant sources of extrarenal, extra-adrenal active renin in rats, potentially originating from macrophages.

Rong et al. (1999) studied this question.

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