Key result
A high-fat high-sucrose diet decreased tolerance to ischemia-reperfusion injury similarly in both male and female rats compared with controls.
Why the study?
Prediabetes strongly predicts type 2 diabetes and cardiovascular complications, but sexual dimorphism in this setting remains rarely explored.
Does sex influence the physiological response to a high-fat high-sucrose diet and myocardial tolerance to ischemia-reperfusion injury in rats?
Does sex influence the physiological response to a high-fat high-sucrose diet and myocardial tolerance to ischemia-reperfusion injury in rats?
In a rat model, a high-fat high-sucrose diet induces similar susceptibility to myocardial ischemia-reperfusion injury in both sexes despite sexually dimorphic systemic physiological responses.
Sex-specific metabolic responses to HFS diet in rats but similar I/R tolerance; leaves open human relevance and prospective validation.
Prediabetes is a strong predictor of type 2 diabetes and its associated cardiovascular complications, but few studies explore sexual dimorphism in this context. Here, we aim to determine whether sex influences physiological response to high-fat high-sucrose diet (HFS) and myocardial tolerance to ischemia-reperfusion injury. Male and female Wistar rats were subjected to standard (CTRL) or HFS diet for 5 months. Then, ex-vivo experiments on isolated perfused heart model were performed to evaluate tolerance to ischemia-reperfusion injury. HFS diet induced fasting hyperglycemia and increased body fat percent to a similar level in both sexes. However, glucose intolerance was more pronounced in female HFS. Cholesterol was increased only in female while male displayed higher level of plasmatic leptin. We observed increased heart weight to tibia length ratio only in males, but we showed a similar decrease in tolerance to ischemia-reperfusion injury in female and male HFS compared with respective controls, characterized by impaired cardiac function, energy metabolism and coronary flow during reperfusion. In conclusion, as soon as glucose intolerance and hyperglycemia develop, we observe higher sensitivity of hearts to ischemia-reperfusion injury without difference between males and females.
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Fourny et al. (2021) studied Prediabetes and ischemia-reperfusion injury. High-fat high-sucrose diet (HFS) vs. Standard diet (CTRL) was evaluated on Tolerance to ischemia-reperfusion injury. A high-fat high-sucrose diet decreased tolerance to ischemia-reperfusion injury similarly in both male and female rats compared with controls.
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