Key result
A high-fat, high-sucrose diet induced hypertriglyceridemia, which was associated with increased systolic blood pressure and greater mesenteric artery sensitivity to alpha-agonists in female rats.
Why the study?
The effect of hyperlipidemia on the cardiovascular system is uncertain in females.
Does a high-fat, high-sucrose diet alter cardiovascular parameters in female Sprague-Dawley rats?
Does a high-fat, high-sucrose diet alter cardiovascular parameters in female Sprague-Dawley rats?
In female rats, a high-fat, high-sucrose diet induces hypertriglyceridemia, which is associated with increased systolic blood pressure and altered vascular reactivity.
HFHS diet raises systolic BP in female rats via hypertriglyceridemia; leaves open translation to women and requires human confirmation.
The effect of hyperlipidemia on the cardiovascular system is uncertain in females. The aim of the present study was to determine whether administration of a lipogenic diet alters cardiovascular parameters in female rats. Fifty female Sprague-Dawley rats were assigned into 2 groups of rats receiving a standard or a high-fat, high-sucrose diet (HFHS) for 6 weeks (n = 25 per group). Body mass, blood lipids concentrations, triglycerides clearance, blood pressures (BPs), systolic and diastolic functions, as well as vascular reactivity were assessed at the end of the diet intervention. At termination, body mass was similar between the 2 groups. Fasting blood triglycerides concentration (BTG) was greater in the HFHS group. Triglycerides clearance was impaired in the HFHS group. High-density lipoprotein (HDL) cholesterol concentration was lower in the HFHS group. The early-to-late diastolic filling velocity ratio (E/A) was lower in the HFHS group and negatively associated with BTG. The sensitivity (EC 50 ) of mesenteric arteries to phenylephrine was greater in HFHS and was negatively associated with BTG, but not HDL. Systolic BP was higher in the HFHS group and was positively associated with BTG and HDL. The association between systolic BP and BTG was independent of other lipids measured. In conclusion, hypertriglyceridemia may have increased resistance arteries responsiveness to alpha-agonist and systolic BP in female rats.
No takes yet. Share an insight, caveat, or question.
Mogane et al. (2019) studied Hyperlipidemia (n=50). High-fat, high-sucrose diet (HFHS) vs. Standard diet was evaluated on Cardiovascular parameters including blood pressure, diastolic function, and vascular reactivity. A high-fat, high-sucrose diet induced hypertriglyceridemia, which was associated with increased systolic blood pressure and greater mesenteric artery sensitivity to alpha-agonists in female rats.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: