Why the study?
Does cTCDS with a galactose-based contrast agent and Valsalva maneuver improve the diagnostic sensitivity for detecting right-to-left shunt compared to agitated saline or no Valsalva in stroke patients with PFO?
Does cTCDS with a galactose-based contrast agent and Valsalva maneuver improve the diagnostic sensitivity for detecting right-to-left shunt compared to agitated saline or no Valsalva in stroke patients with PFO?
Contrast transcranial Doppler sonography using a galactose-based contrast agent combined with the Valsalva maneuver provides 100% sensitivity for detecting right-to-left shunts in stroke patients.
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May improve RLS detection sensitivity in PFO-related stroke; leaves open need for prospective validation before practice change.
Üzüner et al. (2004) studied this question.
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