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May 1, 1999Stroke

Contrast Transcranial Doppler Ultrasound in the Detection of Right-to-Left Shunts

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Why the study?

Does contrast transcranial Doppler ultrasound accurately detect cardiac right-to-left shunts compared to transesophageal echocardiography?

Population

54 patients investigated for cardiac right-to-left shunts

Comparison

Bilateral contrast transcranial Doppler… vs Transesophageal echocardiography (TEE)

Design

Cross-sectional

Authors

DDDirk W. DrosteBoston UniversityMRMartina ReisenerUniversity of MünsterVKVendel KeményRegional Environmental Center for Central and Eastern Europe

Discussion

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Implication

TCD may support sensitive shunt detection versus TEE; leaves open the need for prospective validation before clinical adoption.

Structured PICO

Does contrast transcranial Doppler ultrasound accurately detect cardiac right-to-left shunts compared to transesophageal echocardiography?

P
Population
54 patients investigated for cardiac right-to-left shunts
I
Intervention
Bilateral contrast transcranial Doppler ultrasound (TCD) of the middle cerebral artery using agitated saline (9 mL) or a galactose-based contrast agent (5 mL), with and without Valsalva maneuver, performed twice
C
Comparator
Transesophageal echocardiography (TEE)
O
Outcome
Detection of cardiac right-to-left shuntssurrogate

Contrast transcranial Doppler ultrasound performed twice with saline or galactose-based contrast is a sensitive method for identifying cardiac right-to-left shunts compared to transesophageal echocardiography.

Cite This Study

Droste et al. (1999) studied this question.

synapsesocial.com/papers/6a7e8405b2811efa75cd9ba4https://doi.org/10.1161/01.str.30.5.1014

Topics

Echocardiography
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Selection of Patients for Transesophageal Echocardiography After Stroke and Systemic Embolic Events1995 · 107 citations
  2. 2Stroke recurrence in patients with patent foramen ovale1996 · 417 citations
  3. 3Validation of Transcranial Doppler Sonography in the Assessment of Patent Foramen Ovale1995 · 55 citations
  4. 4Transesophageal echocardiography and contrast‐TCD in the detection of a patent foramen ovale1994 · 188 citations
  5. 5The Effect of Different Settings of Ultrasound Pulse Amplitude, Gain and Sample Volume on the Appearance of Emboli Studied in a Transcranial Doppler Model1994 · 33 citations