Key result
Type 2 diabetes mellitus was associated with a 29% decrease in cardiac myofilament Ca2+ sensitivity compared to nondiabetic controls (P<0.05).
Why the study?
Is cardiac myofilament function altered in human patients with Type 2 diabetes mellitus compared to nondiabetic controls?
Case-Control (n=12)
Is cardiac myofilament function altered in human patients with Type 2 diabetes mellitus compared to nondiabetic controls?
Effect estimate: 29% decrease
p-value: p=<0.05
Human Type 2 diabetes mellitus is associated with depressed cardiac myofilament Ca2+ responsiveness, providing a potential cellular mechanism for diabetic cardiomyopathy.
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May underlie diabetic cardiomyopathy; extends animal data to humans but leaves open clinical relevance.
Jweied et al. (2005) conducted a case-control in Type 2 diabetes mellitus (n=12). Type 2 diabetes mellitus vs. Nondiabetic patients was evaluated on Cardiac myofilament Ca2+ sensitivity (29% decrease, p=<0.05). Type 2 diabetes mellitus was associated with a 29% decrease in cardiac myofilament Ca2+ sensitivity compared to nondiabetic controls (P<0.05).
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