Why the study?
Does type 1 diabetes impair myocardial Ca(2+) handling and cause diastolic dysfunction in a rat model?
Population
Streptozotocin-induced diabetic rats and isolated ventricular myocytes
Comparison
Streptozotocin-induced type 1 diabetes vs Age-matched placebo-treated rats
Design
Preclinical
Authors
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Impaired Ca²⁺ handling may underlie diastolic dysfunction in type 1 diabetes; leaves open translation from rat myocytes to clinical practice.
Does type 1 diabetes impair myocardial Ca(2+) handling and cause diastolic dysfunction in a rat model?
Impaired calcium reuptake during myocyte relaxation is a key mechanism underlying subclinical diastolic dysfunction in type 1 diabetes.
Lacombe et al. (2007) studied this question.
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