Key result
Among elderly Japanese patients with non-valvular atrial fibrillation, 91.9% received oral anticoagulants, although 20-30% of those on direct oral anticoagulants received inappropriately low doses.
Observational (n=32,713)
Yes
In elderly Japanese patients with non-valvular atrial fibrillation, over 90% receive oral anticoagulants, but inappropriate underdosing of DOACs is highly prevalent.
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Inappropriate low-dose DOAC use appears common in elderly AF; this Level 5 registry data leaves open outcome impact and practice implications.
In the ANAFIE Registry, >90% of elderly Japanese AF patients received OAC therapy, mostly DOACs. Inappropriate low doses of DOACs that did not fulfill dose reduction criteria were prescribed in 20-30% of patients.
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Akao et al. (2020) conducted an observational in Non-valvular atrial fibrillation (n=32,713). Oral anticoagulants vs. No oral anticoagulants was evaluated on Prevalence of oral anticoagulant use. Among elderly Japanese patients with non-valvular atrial fibrillation, 91.9% received oral anticoagulants, although 20-30% of those on direct oral anticoagulants received inappropriately low doses.
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