Why the study?
Does oral anticoagulant use reduce stroke or increase major bleeding in a real-world community cohort of patients with atrial fibrillation?
Population
3,282 patients with atrial fibrillation from a community-based prospective survey in Fushimi-ku, Kyoto, Japan.
Comparison
Oral anticoagulants (mainly warfarin) vs No oral anticoagulants
Design
Cohort
Follow-up
1 year
Authors
Loading...
Equivalent outcomes do not support altering OAC decisions; leaves open effectiveness under guideline-concordant use in community AF.
Does oral anticoagulant use reduce stroke or increase major bleeding in a real-world community cohort of patients with atrial fibrillation?
In a real-world Japanese cohort, inappropriate use of oral anticoagulants (overuse in low-risk, underuse in high-risk, and sub-therapeutic dosing) resulted in no significant difference in stroke or bleeding outcomes compared to no treatment.
Akao et al. (2014) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: