Key result
Among low-osmolar non-ionic radiocontrast media, iopromide was associated with the highest incidence of immediate adverse drug reactions (1.03%), while iobitridol had the lowest (0.34%).
Why the study?
Does the incidence of immediate adverse drug reactions vary among different low-osmolar non-ionic radiocontrast media and between single versus multiple CT examinations per day?
Observational (n=142,099)
No
Does the incidence of immediate adverse drug reactions vary among different low-osmolar non-ionic radiocontrast media and between single versus multiple CT examinations per day?
Absolute Event Rate: 1.03% vs 0.34%
The incidence of immediate adverse reactions to low-osmolar non-ionic radiocontrast media varies significantly by specific agent, and the risk is compounded by multiple CT scans in a single day.
No takes yet. Share an insight, caveat, or question.
May inform contrast selection to minimize immediate reactions; observational data leave open need for randomized confirmation.
Kim et al. (2016) conducted an observational in Patients undergoing RCM-contrasted CT examinations (n=142,099). Iopromide vs. Iobitridol was evaluated on Immediate adverse drug reactions. Among low-osmolar non-ionic radiocontrast media, iopromide was associated with the highest incidence of immediate adverse drug reactions (1.03%), while iobitridol had the lowest (0.34%).
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